Would be very hard. You'd need not only a decent amount of skill in programming but would be very fluent in Japanese as the literature is pretty much exclusively Japanese. Then you've got the very hard task of tracking down the literature itself, getting a working system etc. Also, the fact that the PC-FX wasn't extensively programmed for means that you'd have to do a hell of a lot of work yourself.
Still, the system has been emulated by Western programmers, so theres hope yet.