Here's a real doozy that I've recently run into, I just finished modding a Duo-R for S-video and when I went to test it, I got absolutely no video whatsoever, even with composite video using an AV cable. I will admit that I accidentally bridged some pins when I decided to use pins 21 and 22 for 5V, but I was able to fix that problem with a little desoldering braid and there are no other shorts on the HuC6260 or anywhere else.
Is there a possibility that the 6260 suffered heat damage when I used that desoldering braid? I find it somewhat improbable since I didn't leave the braid on for very long and I didn't have my iron on a high temperature.