Ha! I don't know, so many of them really don't stand out for me....
For consistent quality, I'd go with: Cheers, Cosby Show and Golden Girls
But these shows lacked KIDS doing GOOFY stuff, so of course I couldn't vote for any of the sitcoms.
Charles in Charge always had a special place in my heart, but it really doesn't stand out from the others... and I really didn't like Saved By the Bell back in the day, but now I actually watch it (occasionally).
So what does that say? Clearly, I've lost my mind.