You guys are kidding right? The Astroboy TV show was on American TV 50 years ago, the manga was 60 years ago. It's influenced dozens of other creations. Megaman and Zonk are just the most obvious.
Seriously, Astro Boy is super f*cking awesome. That new bullshit Ridiculius Cage movie can take a flying f*ck at the moon, but the original manga is pure gold. Some of the best science fiction ideas of the 60s and 70s are in those little books.
I also recommend the GBA game. It's one the best games on the system.