The CD Detect signal isn't necessarily needed if you rewrite the BIOS. That signal may be more important to the actual CD-ROM drive, which if you rewrite the BIOS you can bypass that.
Okay, let's assume CD-Detect isn't needed.
Which bios are you going to re-write?
If 1.0, there go all the later games.
if 2.x, there goes altered beast (and a few others, iirc) and the super cd games.
if 3.x, no altered beast, but most everything else should play.
In any case, you're not going to get -all- the isos to play, unless you want to detect which program it is, and switch bios images. Good luck with that....
(I've never said it -can't- be done, though. It's just more trouble than doing an ide converter.)