YMMV
http://www.gamasutra.com/view/news/176663/5_tips_for_making_great_animations_for_2D_games.php#.UIayA2_A-5LIntro from the article:
In this era dominated by 3D games, when even the latest versions of Street Fighter and Super Mario Bros. are made up of polygonized characters, quality sprite-based 2D games are rare.
Many now consider the process behind making beautifully animated productions like Metal Slug or Aladdin to be a lost art, forgotten and undervalued as developers chased the excitement and economy of 3D graphics.
But there are still a handful of gorgeous sprite-based games that release every once in a blue moon, and a few have had the fingerprints of animator Paul Robertson all over them, like Ubisoft Montreal's highly-regarded Scott Pilgrim vs. the World: The Game.
Robertson's style is immediately recognizable, featuring short and stocky figures that look like River City Ransom characters brought up to modern standards, with much more detail and personality packed into each frame.
His latest work can be found in Mercenary Kings, a soon-to-be-Kickstartered 2D run'n gun developed by the Ubisoft Montreal veterans at Tribute Games (Wizorb). Jonathan "Persona-sama" Kim, also an animator on Scott Pilgrim and other titles like Skullgirls, is on board for the PC title, too.