GUTS, I don't think the Shuttle's controller will make a significant difference as far as your comfort is concerned. Of course, I hope I am wrong, but, for me, the Shuttle pad feels like the standard PCE pad.
HOWEVER, I think we have different preferences for pad design (and possibly different methods for holding the damn things). As we have discussed in the past, I much prefer PCE/NES pads over Genny's.
Perhaps modifying a Genny controller for use on the PCE is possible? (I am clueless when it comes to these things.)