"Best potential sound" for what, homebrew? The HuC6280A takes the punch out of some of Air Zonk's sound effects, and there's at least one game whose name I can't recall off-hand where the music is a clicky mess with the HuC6280A.
Edit: "Kaizou Choujin Shubibinman" is the game with the clicking problems on HuC6280A. Though reconsidering after testing a number of games, it's likely there are many more games that sound subjectively "better" on the HuC6280A than sound worse.