I've worked on a lot of these which is how I could tell who had worked on it prior. Basically anything gamedoctorhk sells that is listed as junk usually has some pretty odd issues. Otherwise he would have fixed them himself since he sells systems as well. In all honesty I would get a hold of thesteve here in the forums. This problem sounds like it could be a bad chip on the motherboard and that type of repair is right in his wheel house.
Oh, one more thing I just thought of. It might be bad traces going from the pins of the Hu card slot. This can also cause the no bios on startup. Especially since you said a region mod was done before. Maybe whoever did the region mod damaged something. Check the traces underneath the board to see if they all have continuity for the pins that had been tampered with.