I don't think sampling on the first two is a good idea incase you want to use LFO (leads).
Are you talking about hardware LFO? Lol nobody..
nobody should be using hardware LFO to do... regular LFO stuffs. If you want to do non-musical screetchy stuff, kinda like what ccovell showed, then I guess. But I personally think it's a huge waste of a channel, for a system that already should have had a couple more, when you can do so much more interesting sounds with pairing the channels in phase, etc.
I though this was general knowledge, but if not: Every PCE channel is capable of software LFO, and isn't plagued like the master system, or triangle channel on nes, and other systems of that era where you get frequency artifacts when you change the high and low ports of the period system. PCE doesn't have any of those problems with any of its channels, making hardware LFO useless 99.9999% of the time.