Thanks for the link to that ASUS board, what OS can you put on that thing? I will start researching it, looks rad.
It's the same CPU, running at the same speed, with the same ... everything really, as the original RetroBlox prototype that they showed. The huge difference is that it doesn't come with the cartridge slots and controller ports build into it.
Most folks can just buy cheap USB-to-whateverjoypad adapters if they care ... or someone could wire up the I/O pins on the Tinker Board and write a driver ... just like nullity's peeps have done.
As for the OS, it runs a customized version of Debian linux if you need to use it's 4K HD video-playback hardware, or you can run a more-standard Debian distribution and run whatever you like on it, such as RetroArch and all of its emulators.
The RetroArch guys are working on adding support for it to their stand-alone Lakka operating-system-plus-emulators-and-do-everything-out-of-the-box ... but it's not there quite yet.
The point is ... it's open, it's supported, it's fixable, but you're actually going to have to read some web pages to get it working.
The POLYMEGA
promises to be a closed-environment one-stop-shop solution for something that's basically-the-same-but-may-be-better.
We really don't know at this point.
You can probably tell from my language, which basic approach I personally prefer ... but that's not important.
The critical question (IMHO), is whether these guys can actually pull off what they promising. If so, then there are potentially a lot of people who would be happy with this.