SNK maskes some good points.
Design flaws, nothign much easy you can do to prevent problems due to that, however where you place your system can make a difference.
Newer systems, and even systems such as the Sega Genesis, should be kept on a flat surface. Tile, Wood, Glass, etc. Don't place a system on a carpet. It traps the heat. You want air to circulate aroudnt he system. if your system is missing "feet" (common with some older systems), buy some and place them on the bottom fo the system.
Airflow and the air temperature around the system is important. Don't place systems on top of a cable box or some other component that puts out heat. If the system has a fan, don't block the in or out ports.
Buy a dust cover, even if you use the system daily. You don't have to buy one specific for your system (though, they are out there), finding one similarly sized at an electronics store (Printer cover, etc) can help. It may not fit snugly, though it will do the job. Many dust covers are also water resistant, so you have some protection against spills. I use a Turntable dust cover on one system, and a printer dustcover for my Duo-R and Genesis.