Always leave that noise reduction shit off.
Actually on my 36" Sony Wega that I had, depending on what I was doing, I would turn the DNR on it to high or middle for some games or movies, and it would make them look better. That TV was nice. Now I'm wishing I had just kept it.
I had all the settings to my liking and had 2 main modes I used: one vibrant mode for games and so on, and one calibrated mode set pretty close to NTSC J for movies. Turbo games looked great on it, as did PS2 and other systems, with no need for adjustments. It was just too damn heavy though. I don't find lifting 250lbs with another person, 'fun times'. I could always grab a 27" model of the same TV, but honestly I have my eye on another one that I test modeled before the unit I have now (the one I actually wanted), and I can get it for the same price or cheaper after shipping and with warranty, than people are selling the 27" of my old one used.