Answer: I don't know. However...
In addition to any new circuitry that the interface contains (for example, the interface unit contains 2K RAM for backing up save files), you would need the BIOS (System card 2.01 or 3.01). I know you were focusing on the hardware requirements, but I mention the BIOS because it looks for the 2K RAM--and I am not certain what happens if it doesn't find it. I believe some CD-ROM games will allow you to play, but warn you that you won't be able to save your progress. Other games, though, might require a minimum amount of space for a save file.
The gurus here can help you, I'm sure.