I haven't voted yet, because, well, I want to think about it before casting a final vote. I really like sunteam_paul's long list of suggestions, though! Great stuff in there.
Am I lame for wanting a JJ & Jeff theme? You control a bird (or dog, player selectable) from JJ & Jeff that deposits little "piles" whilst running through the maze corridors (akin to sunteam_paul's tank idea). JJ, Jeff, Kato and Ken are the "ghosts", cans of Coca-Soda are the pellets, etc... the intermission scenes feature everybody we love...
I would always play as the "bird", because it would be fun to fly around the mazes corridors...
I vote Zelda (rip-off) style. Control Link, collect rupees, get chased by moblins, collect "master sword pelettes" to chase moblins with (or maybe even shoot them with), find hidden keys to open locked areas on the map.
Do a Neutopia-themed version. Come-on, nobody will know.
Scorpits! Ghostcloths! Oh my!
This is my favorite one...