I purchased a PC Engine Duo, knowing that it had no audio. I'd never gotten my hands on one before, but my best friend was kinda nuts over the TG-16 stuff, and after I bought him a Turbo Everdrive as a birthday gift and watched him go apeshit over it, I kinda got interested myself.
I went through a lot of trouble repairing the Duo, and I have tumbled to some knowledge through a great deal of time, swearing, and frustration that I think others ought to know:
1 - Regardless of how well your Duo works when you get it, replace all caps immediately. Duos are noted for the poor quality of their caps, and this is not to be understated. I found that the trace under one of the pre-amp caps was completely destroyed by the cap's failure. Repairing traces is never a fun thing to do.
2 - When removing the SMT caps, I know a lot of people advocate the 'twist 'em off' method. Please, for the love of all that is holy, do not do this. Sure, it's quick, but it only takes one pulled trace to f*ck up an expensive piece of vintage technology for good. Take your time; use a soldering iron to heat up the legs one at a time and gently pull the heated side up. Inch each leg up a bit at a time, switching sides as needed, until the cap is free. It'll take time, but better safe than sorry.
3 - Get a frequency counter if you want to adjust VR105. It doesn't have to be hugely expensive, but you'll need at least a 10MHz model (preferably 20MHz, just to be safe), and you'll need to know how to use it. I got an old (looks like 70s or 80s model) counter for $15 off of eBay, and it works a treat. Definitely gonna save up for a scope next. VR105 adjusts VCO, which needs to be (ideally)4.3218MHz. Obviously, the closer you get to this value, the better your Duo will run. I've managed to get it spot-on, and my games load noticeably more quickly.
[ul][li]Disconnect the power to your system[/li][li]Connect the counter lead (typically the red lead in a red/black pair) to Pin 1 of Connecter P6[/li][li]Connect the ground lead (black) to Pin 5 of Connector P5[/li][li]Reconnect the power to your system and put a CD (a game works best) on the spindle, and press RUN[/li][li]Using a small screwdriver (ideally plastic), adjust VR105 until you get a consistent 4.3-4.4MHz reading. It's better to go a little high than to be a little low on the reading, so remember that if you can't get it perfect.[/li][/ul]
4 - One of the problems I encountered that really frustrated me was that CD audio would play decently sometimes, and sometimes it would get scratchy and/or drop out until a new track needed to load. This is due to either VR101 or VR103. I recommend going after VR103 first; it's more likely to be your culprit, and unlike VR101, if you take it out of range, it's far less likely to prevent games from loading. Load up CD game with a sound-test feature (Rondo of Blood is a good choice, because it has an immediately-accessible sound test that will cover the whole range of the CD), and, using Rondo of Blood as an example, select the last music track and play it. If it crackles or cuts out at any point, use a small plastic screwdriver to make very small movements to VR103. In my instance, I had to rotate it slightly anti-clockwise, but your mileage may vary.
5 - One size does not fit all. I know that there is a rather incomplete Excel matrix of readings off of the trimpots, but when I set my pots to those readings (even the 'average' readings), my Duo kept on failing to load games, playing them with audio errors, or having crazy load times (2-3 minutes to start a game, and sometimes failing to find needed data during an in-game load totally). Each Duo appears to be a thing unto itself. Only VR105 requires an absolute value, everything else is...flexible. This also put me in the awkward position of having to re-determine multiple pots, which brings us to number six...
6 - One pot at a time! I cannot stress this enough - only work on one pot at a time. When you think you have that pot correct, test, test again, and test yet again, before going back and testing once more before you even consider moving on to the next pot. If you fiddle with several things at once, you're far more likely to f*ck things up badly, which is why you should always, always, ALWAYS mark the initial setting with a fine-tipped permanent marker or get AB AC BC multimeter readings, so if you do screw the proverbial pooch in your adjustments, you can return to the original settings and try again.