I think TG-16-only players probably notice it more since audio in general is less common on US releases and the more "multi-media" stuff got skipped. When you do hear it, it will stand out.
PCE games tend to be more voice heavy and this sort of shitty audio is super common so its not anything special. Its used in many many cinemas to save disc space. Many PCE RPGs, digital comics, etc have more audio than you can fit on a standard audio CD so it was either this or go to multiple discs (which, for some reason, was never done on PCE).